常時英心:言葉の森から 1.0

約10年間,はてなダイアリーで英語表現の落穂拾いを行ってきました。現在はAmeba Blogに2.0を開設し,継続中です。こちらはしばらくアーカイブとして維持します。

動詞〜 to the point where S+V

これが治験を経て、応用されることになるのを心待ちにしています。いあや、ぜひそうなってほしいものです。

Team alleviates Alzheimer's symptoms in mice with gene therapy

A research team has used gene therapy to alleviate Alzheimer's symptoms in mice to the point where their memory became comparable to that of normal mice.

The treatment marks the first ever such success, and was accomplished by a team including Takaomi Saido, senior team leader at Riken Brain Science Institute, and Nagasaki University professor Nobuhisa Iwata. The results were published in a British science journal on Aug. 18, and the team plans to proceed with tests on primates and then do clinical tests once they can confirm the safety of the treatment.

Alzheimer's disease occurs when an unnecessary protein called beta amyloid overstocks in the brain, destroying nerve cells. The research team in 2001 discovered an enzyme called neprilysin that breaks down beta amyloid. Afterwards, research around the world found that when this enzyme's activity falls, Alzheimer's sets in.

The research team developed a virus carrying genes that produce neprilysin and injected it into mice with early-stage Alzheimer's disease. The beta amyloid in the mice fell by half to near the amount of a healthy mouse. When measuring the time needed by the mice to reach a goal in a maze as a test of their memory, they were about the same as regular mice.
There are around 2 million Alzheimer's patients in Japan, and it is thought to take around 20 years after the beginning of beta amyloid accumulation for symptoms to appear. Saido says, "Getting immunization after reaching a certain age could lead to prevention."

March 19, 2013(Mainichi Japan)
http://mainichi.jp/english/english/newsselect/news/20130319p2a00m0na003000c.html

標題の構文は「SVというところまでアルツハイマーの症状を緩和する、和らげる」という意味です。to the point where/ of~で「〜という段階まで、状態まで〜できる」という箇所が効いています。このような上質な言い回しは丸ごと覚えて使いたいですね。

昔、米国人のJean先生に言われ続けていた Read it aloud again and again to the point of instant recall!という言い回しを思い出しました。(UG)